What does a Gleason score of 8 mean?
A Gleason score of 8 or higher, accompanied by a PSA level of higher than 20 ng/ml and a more advanced tumor stage, signifies a high risk of advancing cancer. In high-risk cases, the prostate cancer tissue looks very different from normal tissue.
What stage is metastatic prostate cancer?
Patients with disease that has spread to distant organs, most commonly the spine, ribs, pelvis and other bones have metastatic stage IV or D2 prostate cancer. Prostate cancer diagnosed in this stage is often difficult to cure, although patients may live for several years with effective treatment.
What is the life expectancy with a Gleason score of 8?
The survival expectancy for men with Gleason 8–10 adenocarcinoma of the prostate treated with hormonal therapy was 6–8 years less than that for controls.
How serious is a Gleason score of 8?
Cancers with Gleason scores of 8 to 10 may be called poorly differentiated or high-grade. These cancers are likely to grow and spread more quickly, although a cancer with a Gleason score of 9-10 is twice as likely to grow and spread quickly as a cancer with a Gleason score of 8.
Can you live 10 years with metastatic prostate cancer?
Of the 794 evaluable patients, 77% lived < 5 years, 16% lived 5 up to 10 years, and 7% lived > or = 10 years. Factors predicting a statistical significant association with longer survival (P < 0.05) included minimal disease, better PS, no bone pain, lower Gleason score, and lower PSA level.
How long can a person live with metastatic prostate cancer?
Once prostate cancer has spread beyond the prostate, survival rates fall. For men with distant spread (metastasis) of prostate cancer, about one-third will survive for five years after diagnosis.
What is the most aggressive form of prostate cancer?
Small cell carcinoma, the most aggressive type of neuroendocrine cancer in the prostate that develops in small round cells of the neuroendocrine system.
What is the life expectancy of a Gleason 7?
The mean (range) age of the men was 69.5 (59.6-76.2) years and the median (interquartile range) follow-up was 2.6 (0.8-5.0) years; the mean American Society of Anesthesiologists score was 1.8. The 6-year cancer-specific survival (nine patients at risk) was 100%, which sharply contrasted with the 68% overall survival.
How long can you live with 9 Gleason?
Conclusions. 80% of men with Gleason sum 8–10 who undergo RP will experience biochemical recurrence at 15 years. However, CSS approached 90% in men with pathologic organ-confined disease. Higher pathological Gleason sum (9–10), seminal vesicle and lymph node involvement are independent predictors of worse CSS.