What is mitotic index in cancer?

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Is mitotic index higher in cancer cells?

In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer.

Do cancer cells have a high or low mitotic index?

Malignancy is characterized by accelerated cell division (high “mitotic index”), which is detectable on proton (1H) MRS (hereinafter “MRS”) as elevated Cho. Cho elevation occurs when there is rapid cell membrane synthesis.

What does the mitotic index do?

The mitotic index (percentage of cells in mitosis at any time) provides a measure of the capacity of cells to divide and of the rate of cell division. It is used to identify the sites of growth within a tissue and to determine which cell types are dividing.

What is the average mitotic index?

Labelling and mitotic indices were studied in the epidermis of twenty-eight young men. A mean labelling index of 5.5% was found from the whole study and a mean mitotic index of 0.06%. Mitotic index particularly was extremely variable; indices between 0.002 and 0.438% were found in individual biopsies.

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What is a high mitotic count?

The higher the mitotic count, the more likely the tumor is to have metastasized (spread). The logic is that the more cells are dividing, the more likely they will invade the blood or lymphatic vessels and thus spread around the body.

Do benign tumors have a high mitotic index?

Occasionally, the mitotic rate in benign tumors may be brisk, and those with mitotic activity up to 15 mitoses/10 hpf are termed leiomyomata with increased mitotic activity (Fig. 20.81; see Table 20.7).

What is a mitotic count?

Mitotic count is determined most frequently in veterinary pathology, usually at 400× magnification, but the area counted is seldom defined, and the term often reported is mitotic index. Mitotic index is defined as the number of cells undergoing mitosis divided by the number of cells not undergoing mitoses.

What does a high mitotic index value mean?

The mitotic index is a measure of the proliferation status of a cell population (i.e. the proportion of dividing cells) The mitotic index may be elevated during processes that promote division, such as normal growth or cellular repair.

What affects the mitotic index?

The number of cells in mitosis were counted for cells from different regions of the primary root tissue. Interpretation: In general, the mitotic index decreases with increasing distance from the root cap junction.

How is mitotic index used in medicine?

The mitotic index is used for tumor grading of breast and ovarian cancers [8,9]. In addition, mitotic index has been incorporated in the American Joint Committee on Cancer (AJCC) seventh tumor staging system for malignant melanoma, gastrointestinal tumor, and neuroendocrine tumors of the gastrointestinal tract [10].

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