Which type of cells are most sensitive to chemotherapy?
The “normal” cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different parts of the body.
Why are cancer cells more susceptible to chemotherapy?
Because cancer cells divide much more often than most normal cells, chemotherapy is much more likely to kill them. Some drugs kill dividing cells by damaging the part of the cell’s control centre that makes it divide.
Are cancer stem cells sensitive to chemotherapy?
However the cancer stem cells do not share the sensitivity to chemotherapy of their progeny tumour cells, but rather have the characteristic chemotherapy resistance of the tissue specific somatic stem cells.
Which type of cells are least sensitive to chemotherapy?
Stem cells in particular, are thought to show significantly decreased sensitivity to both chemotherapy and targeted drugs (7–9).
What is the most sensitive organ to radiation?
For example, since the blood forming cells were one of the most sensitive cells due to their rapid regeneration rate, the blood forming organs are one of the most sensitive organs to radiation. Muscle and nerve cells were relatively insensitive to radiation, and therefore, so are the muscles and the brain.
Why are rapidly dividing cells more sensitive to radiation?
The reason that rapidly growing cells are sensitive (in the sense that they are easily damaged or killed), is that during cell division, one double-stranded DNA becomes two single-stranded DNA chains.
What type of cancer does not require chemo?
What type of cancer does not require chemo? People with leukemia don’t have to resort to chemotherapy as their only treatment options, thanks to a variety of targeted medicines that are available.
What is CSCs in cancer?
Cancer stem cells (CSCs) are self-renewable cell types that are identified in most types of liquid and solid cancers and contributed to tumor onset, expansion, resistance, recurrence, and metastasis after therapy. CSCs are identified from the expression of cell surface markers, which is tumor-type dependent.
Which is the most radiosensitive tumor?
Radiosensitive tumors include:
When are cells most sensitive to radiation?
Cells in late G2 and mitosis (M-phase) are the most sensitive to radiation, and cells in late synthesis (S-phase) are the most resistant (Fig. 23.10).