Question: Which among the following malignant germ cell tumor has the worst prognosis?

Treatment of Nonseminomatous Tumors

What is the most common malignant germ cell tumor?

Dysgerminoma, the most common malignant germ cell tumor, usually manifests as a solid mass. Immature teratomas manifest as a solid mass with scattered foci of fat and calcifications.

Is giant cell tumor dangerous?

A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.

Is neuroblastoma a germ cell tumor?

Neuroblastoma as a prominent component of a mixed germ cell tumor of testis.

What is germ cell tumors?

Listen to pronunciation. (jerm sel TOO-mer) A type of tumor that begins in the cells that give rise to sperm or eggs. Germ cell tumors can occur almost anywhere in the body and can be either benign or malignant.

What is the survival rate of germ cell tumor?

The 5-year survival rate for teens ages 15 to 19 is 93%. The survival and cure rates also depend on several factors, including the stage of the disease. The cure rate for children with a stage I or stage II germ cell tumor is 90%. The cure rate for a stage III tumor is 87%.

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Do germ cell tumors grow fast?

There are two types of germ cell tumors that start in the gonads, or reproductive organs: seminomas, which are slower-growing, and nonseminomas, which are faster-growing tumors.

Is giant cell tumor life threatening?

Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations.

How often do giant cell tumors come back?

Clinically, GCT presents as a benign but often aggressive lesion with a tendency toward local recurrence. Depending on the type of treatment and the local presentation of the tumor, recurrence rates range from 0% to 65% (Table 1) [1, 3, 5, 6, 15, 20, 25, 26, 29, 31, 37, 38, 40, 43, 50].

How do you treat germ cell tumors?

Most patients with a cancerous germ cell tumor will need chemotherapy. The drugs that are commonly used for treating germ cell tumors include bleomycin (available as a generic drug), cisplatin (available as a generic drug), etoposide (Etopophos), and ifosfamide (Ifex).

Do germ cell tumors come back?

How do providers treat benign (noncancerous) ovarian germ cell tumors? Healthcare providers remove benign tumors surgically. Sometimes, they need to remove the ovary (or part of the ovary) when removing the tumor. Benign tumors rarely grow back after providers remove them.

What percentage of germ cell tumors are malignant?

Malignant germ cell tumors of the mediastinum are uncommon, representing only 3 to 10% of tumors originating in the mediastinum. They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms.

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Do germ cell tumors run in families?

Familial clustering of testicular malignancies is well documented in literature. Children or siblings of affected family members are at higher risk for testicular germ cell tumors.

What are the causes of germ cell tumor?

The cause of most germ cell tumors isn’t always known. Doctors do know that some medical conditions can make children more likely to develop them. These include: birth defects that involve the central nervous system, genitals, urinary tract, and spine.

Are germ cell tumors genetic?

The cause of germ cell tumors isn’t fully known. Some gene defects passed on from parents to children (inherited) may increase the risk for germ cell tumors. Some genetic syndromes can cause abnormal growth of the male and female reproductive systems.