Is hCG a tumor marker?


What kind of tumors produce hCG?

Among nonreproductive tumors, hepatobiliary tumors (hepatoblastomas, hepatocellular carcinomas, and cholangiocarcinomas) and neuroendocrine tumors (eg, islet cell tumors and carcinoids) are those most commonly associated with hCG production.

Is Alpha hCG a tumor marker?

It is concluded that alpha-HCG represents a reliable marker for malignancy in functioning pancreatic endocrine tumors, and that the presence of NSE establishes the neuroendocrine nature of the tumors.

Is hCG a biomarker?

This chapter is focused on human chorionic gonadotropin (hCG), a hormone with a variety of functions and widely used as a tumor biomarker in selected tumors.

Which hormone is work as Tumour marker?

Human chorionic gonadotropin (hCG), normally produced by the placenta, is also a product of certain types of testicular cancers. Thus hCG is considered an ectopi- cally produced hormone tumor marker. Enzymes can similarly act as tumor markers when pro- duced ectopically or in excessive amounts.

Do tumors produce hCG?

Some abnormal tissues, tumors, and cancers, however, may also produce hCG, making the hCG test useful as a tumor marker. This test measures the amount of intact hCG, and sometimes the beta subunit of hCG, in the blood.

What cancers cause high hCG levels?

Ovarian and testicular cancer can dramatically increase hCG levels. Other cancer types, such as breast and lung cancer, may also increase hCG blood levels.

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What medical conditions cause high hCG levels?

Although the most common cause of an elevated HCG level in females is pregnancy, occasionally, a HCG-secreting tumor is suspected and other conditions such as gestational trophoblastic disease (GTD), nontrophoblastic neoplasms, or a pituitary source of HCG, must be considered.

How Much Can hCG increase testosterone?

The mean serum testosterone level was significantly increased after hCG treatment (baseline, 2, 4, 12, and 24 weeks: 0.90±1.35 ng/ml, 1.77±1.31 ng/ml, 3.74±2.24 ng/ml, 5.49±1.70 ng/ml, and 5.58±1.75 ng/ml, respectively; p<0.05).

When does hCG level increase?

hCG levels usually consistently rise until around week 10–12 of your pregnancy, when the levels plateau or even decrease. This is the reason why pregnancy symptoms can be greater in the first trimester and ease off after this time for many women. In early pregnancy, hCG levels usually double every two to three days.