Quick Answer: How does letrozole work for ovarian cancer?

Can letrozole shrink tumors?

Sixty percent of women taking letrozole showed tumor shrinkage after four months on the drug, whereas 41 percent of women taking tamoxifen showed tumor shrinkage. Patients taking letrozole also underwent fewer mastectomies (complete breast removal) than women who were taking tamoxifen.

How effective is letrozole for cancer?

In the intention-to-treat analysis, women who received letrozole alone had a disease-free survival rate of 73.8 percent at 8 years, compared with a rate of 70.4 percent for women who received tamoxifen alone.

How long should you stay on letrozole?

Most people are given letrozole for 5 years, but some will take it for up to 10 years. Common side effects can be like menopause symptoms and include hot flushes, difficulty sleeping, tiredness and low mood. Side effects usually improve after a few months as your body gets used to the medicine.

What does letrozole do to your body?

Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.

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Do you gain weight with letrozole?

Weight gain is one of the occasional side effects that can occur when taking letrozole but if you are finding it difficult to control then it may be worth getting in touch with your doctor to let them know.

Should letrozole be taken morning or night?

Letrozole is taken once a day in tablet form. The pills are taken at the same time each day, either in the morning or at night. Always take the pills exactly as your nurse or pharmacist has told you. This is important to ensure that it is working as well as possible.

Can I take vitamin D with letrozole?

No interactions were found between letrozole and Vitamin D3. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

How much does letrozole reduce the risk of recurrence?

However, at 7 years, extended letrozole conferred a 28% reduction in cumulative incidence of distant recurrence (HR = 0.72; 95% CI, 0.53-0.97) and a 29% reduction in cumulative incidence of breast cancer–free interval events (HR = 0.71; 95% CI, 0.56-0.89).

Should I continue to take letrozole after 5 years?

Letrozole is usually taken for five years, although some women take letrozole for five years after completing five years of the hormone therapy tamoxifen.