What does a positive FISH test mean bladder cancer?
A positive result is consistent with a diagnosis of bladder cancer or bladder cancer recurrence, either in the bladder or in another site within the urinary system. A negative result is suggestive of the absence of bladder cancer but does not rule it out.
What does FISH mean in cancer?
Fluorescence in situ hybridization (FISH) is a test that “maps” the genetic material in human cells, including specific genes or portions of genes. Because a FISH test can detect genetic abnormalities associated with cancer, it’s useful for diagnosing some types of the disease.
How do I read my fish test results?
How your doctor interprets this test is as follows:
- A result of 0 is negative.
- A result of 1+ is also negative.
- A result of 2+ is considered equivocal (uncertain).
- A result of 3+ is positive.
How accurate is the fish test?
FISH is 42-83% sensitive for detecting pTa and pT1 lesions and 92-100% sensitive for pT2-4 invasive lesions in patients with known bladder cancer, while urine cytology yields sensitivities of 24-50% for pTa and pT1 lesions and 78-85% for pT2-4 invasive lesions.
How is FISH used to diagnose cancer?
Fluorescence in situ hybridization (FISH) is a test that “maps” the genetic material in a person’s cells. This test can be used to visualize specific genes or portions of genes. FISH testing is done on breast cancer tissue removed during biopsy to see if the cells have extra copies of the HER2 gene.
What is FISH test for Down syndrome?
One way to test for Down syndrome is to karyotype fetal DNA; this involves obtaining fetal cells via amniocentesis, then culturing the cells and staining the chromosomes so that they can be visualized under a microscope. A second testing method is fluorescence in situ hybridization (FISH).
How do you read IHC results?
The IHC test gives a score of 0 to 3+ that measures the amount of HER2 receptor protein on the surface of cells in a breast cancer tissue sample. If the score is 0 to 1+, it’s called “HER2 negative.” If the score is 2+, it’s called “borderline.” A score of 3+ is called “HER2 positive.”
What does fish positive mean?
FISH testing usually returns one of two results: positive or negative. Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein. Negative means the protein isn’t involved in the growth of your tumor.
What is FISH analysis used for?
Fluorescence in situ hybridization (FISH) provides researchers with a way to visualize and map the genetic material in an individual’s cells, including specific genes or portions of genes. This may be used for understanding a variety of chromosomal abnormalities and other genetic mutations.
Can FISH results be wrong?
Abnormal FISH results have been used in clinical decision-making (Cheong et al., 2001;Caine et al., 2005;Locatelli et al., 2005), but false-positive results have been reported (Winsor et al., 1999;Weremowicz et al., 2001; George et al., 2003) .
What does HER2 +++ mean?
HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells. In about 1 of every 5 breast cancers, the cancer cells have extra copies of the gene that makes the HER2 protein.
What is FISH ratio?
The interpretation for HER2 FISH testing (HER2/CEP17 ratio and gene copy number) is given below: Positive HER2 amplification: FISH ratio is greater than 2.2 or HER2 gene copy is greater than 6.0. Equivocal HER2 amplification: FISH ratio of 1.8-2.2 or HER2 gene copy of 4.0-6.0.