Why are large doses of chemotherapy given prior to a stem cell transplant?

Why is chemotherapy used for stem cell transplant?

A stem cell transplant lets doctors give higher doses of chemo (sometimes along with radiation therapy). This is because after getting high-dose chemo, the patient receives a transplant of blood-forming stem cells to rebuild the bone marrow.

What chemo is given before stem cell transplant?

To help prepare for stem cell collection, doctors give a medicine called G-CSF (filgrastim),which helps the bone marrow make more stem cells and helps those cells move into the bloodstream. G-CSF is usually started at the end of a regular cycle of chemo and is given daily.

Why do patients need to have chemotherapy before receiving a blood marrow transplant?

Its job is to produce blood cells. If your bone marrow isn’t functioning properly because of cancer or another disease, you may receive a stem cell transplant. To prepare for a stem cell transplant, you receive chemotherapy to kill the diseased cells and malfunctioning bone marrow.

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What is a risk of receiving chemotherapy before a stem cell transplant?

The main risks come from the chemotherapy and radiation treatment before the stem cell transplant. When they destroy the bone marrow, the body is at risk of infection and uncontrolled bleeding. Even a common cold or the flu can be quite dangerous. It can take some time before your blood counts are back to normal.

Is chemo needed after stem cell transplant?

But with a stem cell transplant, doctors can give high doses of chemo because the patient receives a transplant of blood-forming stem cells to restore the bone marrow afterwards. Stem cell transplants are sometimes used to treat lymphoma patients who are in remission or who have a relapse during or after treatment.

How bad is chemo for stem cell transplant?

Most people who have stem cell transplants become infertile (unable to have children). This is not caused by the cells that are transplanted, but rather by the high doses of chemo and/or radiation therapy used. These treatments affect both normal and abnormal cells, and often damage reproductive organs.

What is the life expectancy after a stem cell transplant?

A stem cell transplant may help you live longer. In some cases, it can even cure blood cancers. About 50,000 transplantations are performed yearly, with the number increasing 10% to 20% each year. More than 20,000 people have now lived five years or longer after having a stem cell transplant.

How long is chemotherapy for stem cell transplant?

The average time for the chemotherapy, transplant, and recovery is approximately 3 weeks. Not all transplant centers require that patients remain in the hospital after the infusion of stem cells.

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How long is the stem cell transplant process?

The transplant will usually be carried out a day or 2 after conditioning has finished. The stem cells will be passed slowly into your body through the central line. This process often takes around a couple of hours. The transplant won’t be painful and you’ll be awake throughout.

What can go wrong with stem cell transplant?

Complications From Transplants Using Your Own Stem Cells

infections. interstitial pneumonia (inflammation of the tissue that supports the lungs) liver damage and disease. dry and damaged mouth, esophagus, lungs, and other organs.

What is the longest someone has lived after a bone marrow transplant?

The recipient of a bone marrow transplant in 1963, Nancy King McLain is one of the world’s longest living bone marrow transplant survivors.

Do you lose weight during stem cell transplant?

Upon admission for allogeneic hematopoietic stem-cell transplantation (allo-HSCT) many patients have lost body weight and some may even be malnourished [1, 2]. Weight loss often increases in the peritransplant period [3,4,5,6].