Overview of Origin, Cell Type, Stage and Grade
Where did Kidneycancer originate?
The most common type of kidney malignancy is renal cell carcinoma, which is thought to originate from cells in the proximal convoluted tubule of the nephron. Another type of kidney cancer although less common, is transitional cell cancer (TCC) or urothelial carcinoma of the renal pelvis.
What is the pathophysiology of renal cell carcinoma?
The two most common genes involved in the pathogenesis of RCC are the Von Hippel–Lindau ( VHL) gene and the protein polybromo-1 ( PBRM-1) gene. These will be discussed separately in this article. The most common acquired risk factors for RCC are smoking, hypertension, obesity, chronic analgesic use, and diabetes 7.
Who are most likely to develop renal cell carcinoma?
Most people who have renal cell carcinoma were diagnosed after age 55, and the average age at the time of diagnosis is 71. The condition is relatively uncommon in people younger than age 45. Furthermore, research shows that kidney cancer tends to occur more frequently in men than women.
How bad is renal cell carcinoma?
What Is Renal Cell Carcinoma? It’s the most common type of kidney cancer. Although it’s a serious disease, finding and treating it early makes it more likely that you’ll be cured. No matter when you’re diagnosed, you can do certain things to ease your symptoms and feel better during your treatment.
Which kidney is more important left or right?
The left kidney is located slightly more superior than the right kidney due to the larger size of the liver on the right side of the body. Unlike the other abdominal organs, the kidneys lie behind the peritoneum that lines the abdominal cavity and are thus considered to be retroperitoneal organs.
What is the best treatment for renal cell carcinoma?
Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. Partial or radical nephrectomy may be used, depending on tumor and patient characteristics. Open, laparoscopic, or robotic surgical techniques may be used.