What type of genetic screening tests would focus on the breast and ovarian cancer genes?
One genetic test that is commonly promoted to the public is the test for BRCA1 and BRCA2 gene mutations. Mutations in either of these two genes are tied to cases of inherited breast and ovarian cancer.
What type of genes are BRCA1 and 2?
Mutations in this gene are also transmitted in an autosomal dominant pattern in a family. Both BRCA1 and BRCA2 are tumor suppressor genes that usually have the job of controlling cell growth and cell death. Everyone has two BRCA1 (one on each chromosome #17) and two BRCA2 genes (one on each chromosome #13).
How do I get tested for BRCA gene?
To test for a hereditary BRCA mutation, your doctor or genetic counselor will collect a blood or saliva sample to test your DNA. This sample will be sent to a lab where a technician will look for mutations in your DNA. The lab will then report the results to your doctor or genetic counselor.
Are BRCA1 and BRCA2 the only gene mutations associated with breast and ovarian cancer?
But some mutations in the BRCA1 and BRCA2 genes prevent them from working properly, so that if you inherit one of these mutations, you are more likely to get breast, ovarian, and other cancers. However, not everyone who inherits a BRCA1 or BRCA2 mutation will get breast or ovarian cancer.
What happens if you test positive for BRCA?
A positive test result means that you have a mutation in one of the breast cancer genes, BRCA1 or BRCA2, and therefore a much higher risk of developing breast cancer or ovarian cancer compared with someone who doesn’t have the mutation. But a positive result doesn’t mean you’re certain to develop cancer.
How accurate is genetic testing for breast cancer?
Genetic testing is not 100% accurate. If a test is negative, a person still has a chance of getting breast cancer. If the test is positive, there is still a 15% to 20% chance of not getting breast cancer. Genetic testing is costly, ranging from about $400 to more than $3,000, depending on the type of test.
Can I have the BRCA gene if my mom doesn t?
Because BRCA mutations are hereditary, they can be passed down to family members regardless of gender. This means that if you have a BRCA mutation, you inherited it from one of your parents.
What decisions would you make if you tested positive for BRCA1 or BRCA2?
If you test positive for an abnormal BRCA1, BRCA2, or PALB2 gene and you have never had breast cancer, you now know that you are at much higher-than-average risk of developing it over the course of your lifetime. The average lifetime risk of breast cancer for women is about 12%.
What age should you get tested for BRCA gene?
I typically encourage that children of BRCA carriers wait until they are closer to the age that a BRCA mutation would change their medical management, which is 25 years of age for women and mid-30’s to early 40’s for men.
How much does a BRCA test cost?
The cost of BRCA gene mutation testing varies depending upon what lab is used, and how broad the test is. Some tests look only for a mutation known to run in your family. Others look for a much wider range of mutations. The cost of testing ranges from under $100 to over $2000.
How much does it cost for BRCA testing?
The average cost of genetic testing, if you pay out of pocket, is about $250 but can be higher if multiple genes are analyzed. Genetic counseling often is covered by insurance, especially if there is a family history of BRCA-related cancers.
How much does it cost to be tested for the BRCA gene?
Without insurance, BRCA testing can range from roughly $300 to $5,000 or more, depending on copayments, coinsurance, lab fees, and more.