What is somatic theory of cancer?

What is the somatic mutation theory?

The somatic mutation theory of aging posits that the accumulation of mutations in the genetic material of somatic cells as a function of time results in a decrease in cellular function.

What is an example of a somatic mutation?

Somatic mutations can arise during the course of prenatal brain development and cause neurological disease—even when present at low levels of mosaicism, for example—resulting in brain malformations associated with epilepsy and intellectual disability.

What is somatic oncology?

Overview. Somatic oncology research focuses on the study of cancers resulting from DNA alteration that occurred after conception; i.e., alteration that was not inherited.

What causes a somatic mutation?

Somatic mutations are frequently caused by environmental factors, such as exposure to ultraviolet radiation or to certain chemicals. Somatic mutations may occur in any cell division from the first cleavage of the fertilized egg to the cell divisions that replace cells in a senile individual.

What is wrong for the somatic mutation?

Somatic mutations can occur in any of the cells of the body except the germ cells (sperm and egg) and therefore are not passed on to children. These alterations can (but do not always) cause cancer or other diseases.

Can somatic mutations be repaired?

Somatic mutations are permanent unless altered by genome editing. If a particular treatment eliminates/kills off all cells harboring the particular mutation that lead to the malignant phenotype then you’re not really fixing the mutation. it is possible to revert a mutation, but the process is really rare.

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What are examples of somatic cells?

Every other cell type in the mammalian body, apart from the sperm and ova, the cells from which they are made (gametocytes) and undifferentiated stem cells, is a somatic cell; internal organs skin, bones, blood and connective tissue are all made up of somatic cells.