What cancer is rituximab used for?

What type of cancer is treated with Rituxan?

RITUXAN® (rituximab) is a prescription medicine used to treat adults with: Non-Hodgkin’s Lymphoma (NHL): alone or with other chemotherapy medicines. Chronic Lymphocytic Leukemia (CLL): with the chemotherapy medicines fludarabine and cyclophosphamide.

What are the long term side effects of rituximab?

These adverse events include the development of late-onset neutropenia, defects of immune reconstitution with associated immune compromise, infections, progressive multifocal leukoencephalopathy, reactivation of hepatitis, intestinal perforation and interstitial pneumonitis.

How does rituximab work in cancer?

Rituximab is a monoclonal antibody. It targets a protein called CD20 on the surface of the leukaemia and lymphoma cells. Rituximab sticks to all the CD20 proteins it finds. Then the cells of the immune system pick out the marked cells and kill them.

Is rituximab a cancer drug?

What Is Rituxan? Rituxan (rituximab) is a cancer medication used in combination with other cancer medicines to treat non-Hodgkin’s lymphoma. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

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Will I lose my hair with Rituxan?

Hair loss is a possible side effect of Rituxan. However, in clinical trials, hair loss occurred only in people who took Rituxan for pemphigus vulgaris (PV).

Does Rituxan lower immune system?

Rituximab suppresses the immune system. Therefore, serious fungal, bacterial, and new or reactivated viral infections (for example, hepatitis B or C, shingles) can occur during or after treatment with rituximab.

What does rituximab do to your body?

Rituximab is used to treat certain types of cancer (such as non-Hodgkin’s lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells. Some brands of rituximab are also used to treat rheumatoid arthritis and can decrease joint pain and swelling.

How long can you stay on rituximab?

This can be anything from six months to a few years later. Many people need to have rituximab infusions at least once a year because of how long the treatment lasts. If you have vasculitis your treatment may be more frequent than this.

What is the success rate of rituximab?

Rituximab with bendamustine (Treanda, Cephalon) was studied in a phase 2 trial in patients with relapsed disease. This combination was found to be very effective, with an ORR of 92%.

How many times can rituximab be given?

Administer RITUXAN as a single-agent every 8 weeks for 12 doses. Following completion of 6−8 cycles of CVP chemotherapy, administer once weekly for 4 doses at 6-month intervals to a maximum of 16 doses.

Does rituximab make you tired?

Other side effects commonly seen with Rituximab include skin rash and itching, flushing, nausea, vomiting, fatigue, and headache; cold like symptoms; sensation of tongue or throat swelling; and difficulty breathing, including shortness of breath.

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How long does it take for immune system to recover after rituximab?

Immune reconstitution starts usually after six months with recovery to normal between nine to twelve months. Extended rituximab treatment results in a prolonged recovery of B-cells without an increase of clinically relevant infections.

How safe is rituximab?

Over 540,000 patients worldwide have now received rituximab and serious adverse reactions have occurred in a small minority of patients, but for the great majority of patients, rituximab is safe and well tolerated.

Can rituximab affect your eyes?

In a clinical study concerning the efficacy of rituximab in 222 patients with lymphoma, nine of them reported ocular side effects, including conjunctivitis, transient ocular edema, a burning sensation, a transient or permanent, even severe, loss of visual function.

Is rituximab a steroid?

Rituximab is an efficient and safe treatment in adults with steroid-dependent minimal change disease. Development of steroid dependency in patients with nephrotic syndrome may require a long-term multi-drug therapy at risk of drug toxicity and renal failure.