What are the risk factors for Wilms tumor?

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What are the risk factors of Wilms tumor?

Wilms Tumor – Childhood: Risk Factors

  • Genetic changes. Children may have a mutated (changed), damaged, or missing gene. …
  • WAGR syndrome. WAGR syndrome is a condition that causes a number of birth defects. …
  • Beckwith-Wiedemann syndrome. …
  • Denys-Drash syndrome. …
  • Family history.

What causes a Wilms tumor?

Wilms tumor is a solid cancerous tumor of the kidney that arises from immature kidney cells. For most children with Wilms tumor, no clear cause is known. Certain environmental factors (such as contact with toxic chemicals) may increase the risk of developing this disease, but more research is needed.

How is Wilms tumor prevented?

There are no known lifestyle-related or environmental causes of Wilms tumors, so at this time there is no way to prevent most of these cancers. Experts think these cancers come from cells that were around before birth but failed to develop into mature kidney cells.

What are symptoms of Wilms tumor?

Wilms tumors can also sometimes cause high blood pressure.

Some children with Wilms tumor may also have:

  • Fever.
  • Nausea.
  • Loss of appetite.
  • Shortness of breath.
  • Constipation.
  • Blood in the urine.

Is Wilms tumor hereditary?

Most cases of Wilms tumor are not caused by inherited genetic factors and do not cluster in families. Approximately 90 percent of these cancers are due to somatic mutations, which means that the mutations are acquired during a person’s lifetime and are present only in the tumor cells.

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Is Wilms tumor fatal?

Wilms tumor is a rare kidney cancer that is highly treatable. Most kids with Wilms tumor survive and go on to live normal, healthy lives. Also known as nephroblastoma, Wilms tumor can affect both kidneys, but usually develops in just one.

How long can you live with Wilms tumor?

The 5-year survival rate for children with a Wilms tumor is 93%. However, the rate varies according to the stage of the disease. Stage I, II, and III tumors with a favorable histology have a 4-year survival rate that ranges from 95% to 100%.

Can Wilms tumor came back?

Most relapses (about 85%) occur within two years of diagnosis of the original Wilms’ tumour, but for some children it can come back later than this. For children who relapse, their treatment will depend on what treatment they have already had and what their cancer looks like under the microscope (histology)[1].

Can a Wilms tumor spread?

Wilms Tumor can spread to lymph nodes in the abdomen and to the lung, and rarely to the liver, but does not spread to the bones, bone marrow, or brain.

When is Wilms tumor diagnosed?

It is typically diagnosed in children around age 3 and is rarely diagnosed in those who are older than 6 years of age. About 6 percent of all childhood cancers are Wilms tumors. The condition is named after the doctor who first wrote about this cancer in medical journals.