Frequent question: Why is HER2 positive breast cancer aggressive?

What is the life expectancy of HER2-positive metastatic breast cancer?

With a median follow-up of 48 months, median OS and PFS were 63 months (CI95%, 50-71), and 18 months (CI95%, 15-21) respectively. In 111 patients (26.3%) classified as LTR, median OS was 110 months (CI95%, 95-not reached) versus 56 months in non-LTR patients (CI95%, 47-68).

Is it better to be HER2-negative or positive?

HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast. It is at least two times more likely to return than HER2-negative tumors.

Does HER2-positive mean metastatic?

About 20% of breast cancers are HER2-positive. They usually grow quicker than other types of cancer. Metastatic HER2-positive breast cancer has spread beyond the breast to other parts of the body.

Can you live 10 years with metastatic breast cancer?

What is the prognosis? While there is no cure for metastatic breast cancer, there are treatments that slow the cancer, extending the patient’s life while also improving the quality of life, Henry says. Many patients now live 10 years or more after a metastatic diagnosis.

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Is HER2-positive a death sentence?

“HER2-positive metastatic breast cancer is currently considered an incurable disease, with the majority of patients ultimately relapsing within five years.

Is chemo necessary for HER2-positive?

Trastuzumab and chemotherapy are even recommended for women with very small, HER2-positive breast cancers. Tumors as small as 0.5 cm often warrant such treatment.

Does HER2-positive run in families?

HER2-positive breast cancer is not hereditary, but some other types of gene mutations related to breast cancer are inherited. Genetic testing can tell you if you have any of the mutations currently known to increase risk for breast cancer or other cancers.

Is chemo necessary for HER2-negative?

Hormonal therapy is considered the standard initial treatment for HER2-negative metastatic breast cancer that is also hormone receptor-positive, and is often given in combination with targeted therapy. However, chemotherapy may also be given. A clinical trial may also be an option for treatment at any stage.

What is the survival rate for invasive ductal carcinoma?

What Is Invasive Ductal Carcinoma? Invasive ductal carcinoma describes the type of tumor in about 80 percent of people with breast cancer. The five-year survival rate is quite high — almost 100 percent when the tumor is caught and treated early.

How quickly does invasive ductal carcinoma spread?

According to the Robert W. Franz Cancer Research Center at Providence Portland Medical Center, breast cancer cells need to divide at least 30 times before they are detectable by physical exam. Each division takes about 1 to 2 months, so a detectable tumor has likely been growing in the body for 2 to 5 years.

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Can small breast tumors metastasize?

You will receive an email when new content is published. MADRID — Nearly one-quarter of women with small breast cancers are at risk for distant metastases and may derive benefit from adjuvant chemotherapy, according to a substudy of the MINDACT trial presented at the European Society for Medical Oncology Congress.