Does CA125 detect all cancers?
Blood test (CA125 test)
CA125 is produced by some ovarian cancer cells. A high level of CA125 in your blood could be a sign of ovarian cancer. But a raised CA125 level does not mean you definitely have cancer, as it can also be caused by other conditions such as endometriosis, fibroids and even pregnancy.
What type of cancer does CA125 test for?
Screening in high-risk patients: CA-125 testing is used to screen for ovarian cancer in patients at high risk of developing ovarian cancer due to hereditary cancer syndromes, such as those with inherited BRCA1 and BRCA2 gene mutations.
Can CA125 be high without cancer?
No, a high CA-125 does not always mean cancer is present. Generally speaking, the normal range of CA-125 is considered to be 0-35 units/mL, while a level above 35 units/mL is considered to be a high CA-125 level.
How accurate is the CA125 blood test?
Results: Using a CA125 cutoff of 30 U/mL, an overall sensitivity of 94.8% (96.6% specificity) was obtained when comparing malignancies versus healthy postmenopausal controls, whereas a cutoff of 65 U/mL provided a sensitivity of 83.9% (99.6% specificity).
What is a bad CA 125 level?
In the patient who is being evaluated for a pelvic mass, a CA 125 level greater than 65 is associated with malignancy in approximately 90% of cases. However, without an obvious pelvic mass, this association is much weaker.
What happens if my CA 125 is high?
Results. Results of the CA 125 test are measured in units per milliliter (U/mL). The normal value is less than 46 U/mL. If your CA 125 level is higher than normal, you may have a benign condition, or the test result could mean that you have ovarian, endometrial, peritoneal or fallopian tube cancer.
What level of CA 125 indicates cancer?
The normal range for CA 125 is 0 to 35 units/ml. While a CA 125 level over 35 may indicate cancer, it does not always mean the person has cancer.
CA 125 Levels Chart.
|CA 125 Levels (units/mL)||Potential Cancer|
|>35 (high)||Possible cancer. More tests will be needed for a diagnosis.|
Can you be fully cured of ovarian cancer?
Around two in ten women with advanced-stage ovarian cancer are effectively cured and survive at least 12 years after the treatment as per the research. Your response to cancer therapy and chances for a cure depend on the type and the staging of ovarian cancer at the time of diagnosis.
Can stress cause CA 125 to rise?
The most popular current theories suggest that CA 125 is synthesized by mesothelial cells in response to stress, which can be either mechanical stress caused by fluid overload, or inflammatory stress instigated by the release of mediators such as TNFα and interleukins [5,6].
How can I lower my CA 125 naturally?
However, there are some lifestyle factors you can control to decrease your risk of ovarian cancer.
- Exercise and Diet. By maintaining a weekly exercise regime and a healthy diet, the risk of ovarian cancer decreases. …
- Oral Contraceptives. …
- Avoiding Carcinogens. …
- Pregnancy & Breastfeeding. …
- Healthy Lifestyle.
How high can CA 125 levels go?
High levels of CA 125 (from 125 to 10.000 U/ml and higher) were revealed in 54 from 57 patients (94.7%) with malignant ovarian tumors.
How high is CA 125 ovarian cancer?
Cancer antigen 125 (CA 125) is the only tumor marker recommended for clinical use in the diagnosis and management of ovarian cancer. The reference range of CA 125 is 0-35 units/mL (0-35 kU/L).