Why does tamoxifen increase endometrial cancer?
Tamoxifen. Tamoxifen is a drug that is used to help prevent and treat breast cancer. Tamoxifen acts as an anti-estrogen in breast tissue, but it acts like an estrogen in the uterus. In women who have gone through menopause, it can cause the uterine lining to grow, which increases the risk of endometrial cancer.
Is tamoxifen used to treat endometrial cancer?
Tamoxifen. Tamoxifen is an anti-estrogen drug often used to treat breast cancer. It might also be used to treat advanced or recurrent endometrial cancer. Alternating progesterone and tamoxifen is an option that seems to work well and be better tolerated than progesterone alone.
What does tamoxifen do to the endometrium?
Tamoxifen results in a spectrum of uterine abnormalities including benign alterations such as endometrial polyps, endometrial hyperplasia, endometrial cystic atrophy, adenomyosis, and uterine fibroid growth as well as malignant transformation into endometrial carcinoma and uterine sarcoma[4–8].
How does tamoxifen cause endometrial hyperplasia?
Although the primary therapeutic effect of tamoxifen is derived from its antiestrogenic properties, this agent also has modest estrogenic activity. In standard dosages, tamoxifen may be associated with endometrial proliferation, hyperplasia, polyp formation, invasive carcinoma, and uterine sarcoma.
Can you still get cancer while taking tamoxifen?
Tamoxifen does, however, increase the risk for uterine cancer (endometrial cancer and uterine sarcoma). Still, the overall risk of uterine cancer in most women taking tamoxifen is low, and studies have shown that the benefits of this drug in treating breast cancer are greater than the risk of a second cancer.
Is tamoxifen a form of chemo?
Tamoxifen – Chemotherapy Drugs – Chemocare.
What are the long term side effects of tamoxifen?
Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.
What happens when you stop tamoxifen?
Blood clots in your veins or lungs.
These can occur for up to 2–3 months after you stop taking tamoxifen. Symptoms can include: sudden chest pain. shortness of breath.
How common is endometrial cancer after breast cancer?
There were 83 (4.1%) mortalities due to breast cancer, 63 (3.1%) mortalities due to endometrial cancer and 178 (8.8%) mortalities due to other causes (P<0.05).
Is tamoxifen worth taking?
Tamoxifen is a highly effective breast cancer treatment. It may significantly lower your risk of breast cancer recurrence or invasive breast cancer. People who are at high risk for breast cancer may take tamoxifen to reduce their chances of getting the disease.
How much does tamoxifen reduce the risk of recurrence?
Doctors have long known that five years of tamoxifen reduces recurrence by about half during treatment and by nearly a third over the next five years.
Is it normal to have periods while taking tamoxifen?
Fertility, pregnancy and tamoxifen
For some women, continued use of tamoxifen means periods become less regular, lighter or stop altogether. Generally, your periods will start again once you stop taking tamoxifen, as long as you have not gone through the menopause naturally while taking the drug.