Are multinucleated cells cancerous?
Large multinucleated cells (MNC) commonly exist in cancer cell lines as well as in human cancer tissues. It is known that MNCs often survive after drug treatment of cancer cells cultured in vitro and MNCs of cancer may derive from cell fusion or cell division.
What are multinucleated giant cells?
Multinucleated giant cells (MNGCs) are a special class of giant cell formed by the fusion of monocytes/macrophages abundantly found in human tissues. … Keywords: biomaterial integration; bone regeneration; foreign body cells; macrophage; multinucleated giant cells; osteoimmunology.
What virus causes multinucleated giant cells?
Herpes simplex virus (HSV) and varicella zoster virus (VZV) infections induce the formation of intraepidermal vesicles containing acantholytic cells and multinucleated giant cells in the skin.
Are giant cells normal?
The megakaryocytes, the normal bone-marrow cells thought to be the source of the blood platelets, are also called giant cells. Multinucleated giant cells (micrograph with hematoxylin and eosin stain).
Why are there no giant cells?
The important point is that the surface area to the volume ratio gets smaller as the cell gets larger. Thus, if the cell grows beyond a certain limit, not enough material will be able to cross the membrane fast enough to accommodate the increased cellular volume. … That is why cells are so small.
What is giant cell granuloma?
Central giant cell granuloma (CGCG) is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, scattered throughout the fibrovascular …
How is a tzanck smear performed?
The Tzanck smear is performed by obtaining a scraping from the base of a fresh vesicular lesion after it has been unroofed, spreading and drying the collected material on a glass slide, staining the result with Giemsa, and examining the material with a microscope for the characteristic presence of multinucleated giant …
What is the mechanism of action of acyclovir?
Mechanism of Action:
Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.